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Questions and Answers

Please return to read this page frequently. The contents will change as new information is received from both research and feedback from people using salvestrols.

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Are salvestrols safe?

Even at well beyond the recommended number of Salvestrol Points per day there is no known toxicity, even for diabetics. However, Salvestrols should not be used by pregnant women and breast-feeding mothers.

What's in the capsules?

Salvestrols are made from extracts organically grown citrus (reticulata as found in tangerines and mandarin, clemetine and satsuma oranges), bilberry (European blueberry), raspberry, and strawberry which have not been genetically modified or treated with pesticides or anti-fungal agents (the content of each capsule is listed on the product label). Salvestrols in North America do not contain grape extracts. Salvestrols are encased in vegetable capsules with a rice flour filler. The quantity of magnesium stearate used in the encapsulation process is very small and is vegetable quality specifically designed for use in the manufacture of food products.

Are there any side effects?

There are no known issues with Salvestrol Platinum.

How many capsules should I do?

Until a blood test is available which can measure the presence of the CYP1B1 enzyme, its co-factors and inhibitors, accurate person-specific guidance for Salvestrol use cannot be provided. However, your healthcare professional can access the Practitioner's Area of our website on your behalf and advise you on the current guidelines for maximum effectiveness.

To confront a serious health challenge you should definitely consult a healthcare practitioner for advice. A healthcare professional can guide you on dosage and what to do and what to avoid to enhance the effective of Salvestrols. However, in general Salvestrol Platinum should be used as follows. People of normal weight (BMI 18 to 30) should use a total of six thousand (6,000) salvestrol points per day (4,000 at breakast and the rest at lunch); underweight people should take four thousand (4,000) salvestrol points per day; and heavier people should use eight thousand (8,000) salvestrol points per day. If there is no effect at the recommended starting dose, and you have eliminated factors that could interfere with the effectiveness of Salvestrols (see below), then you can gradually increase the daily intake by a capsule or two per week until the dosage is doubled. Salvestrol capsules should be taken with meals to facilitate digestive uptake. Please note that these guidelines do not apply to children.

For prevention or dealing with a previous health challenge first complete the following cleansing program: four thousand (4,000) salvestrol points per day for at least two months, followed by two thousand (2,000) salvestrol points a day for at least another two months. The cleansing program is required because disease can grow undetected for years so it is necessary to reduce the problem, if it exists, to a manageable level. After the cleansing program, adopt one of the following two regimens:

For a previous health challenge or people at higher risk, continue using at least two thousand (2,000) salvestrol points per day with a meal (either breakfast or dinner).

As a dietary supplement for prevention, take two thousand (2,000) salvestrol points per day.

How should I use salvestrol cream?

Salvestrol Cream is designed for topical use in combination with at least one capsule of encapsulated salvestrol per day. Salvestrol Cream does not work faster or better if more is applied; use only enough to lightly cover the affected area. Salvestrol Cream can be applied several times daily, depending on the severity of the problem, over as large an area as necessary, but should not be applied directly to an open sore. There are no known allergic reactions to Salvestrol Cream.

Will salvestrols interfere with drug therapies?

Salvestrols are a food supplement and should not interfere with drug therapies unless such therapies restrict intake of the fruit sources listed on the product label. Please note that salvestrol products do not contain naringenin, a compound commonly found in grapefruit which may interact with several CYP enzymes and could therefore interfere with some drug therapies.

If you or your physician are uncertain, stop using salvestrols several days prior to treatment and do not continue their use until several days after treatment has finished.

What can help salvestrols work better?

Taking multi-vitamin and multi-mineral supplements at the recommended daily allowance can increase the effectiveness of salvestrols. The specific enhancers are Biotin (Vitamin H, or Coenzyme R), Niacin (Vitamin B3), cobalamin (vitamin B12), magnesium, and selenium. Niacin, in a form that does not cause flushing or a skin rash (Nicotinimide), was previously included but is not present in the current formulation. These enhancers can be commonly found in daily vitamin and mineral supplements.

A Probiotic can improve the uptake of salvestrols; Probiotics are available at any health food store and many drug stores. Probiotic yogurts are available at most grocery stores and if you have problems swallowing capsules you can break them apart and mix them in the yogurt. It is important not to be anemic so a good source of iron is beneficial, as is vitamin C. Exercise is important to increase oxygen levels, especially about three hours after taking salvestrols. Finally, consider eating organic foods as much as possible.

The effectiveness of all the cytochrome P450 enzymes can be compromised when by anemia. It is best to consult a physician to check your iron levels and prescribe a course of action to remedy the situation if they are deficient before doing salvestrols.

What should I avoid while taking salvestrols?

The CYP1B1 enzyme can react with many different substances aside from Salvestrols. The life cycle of the enzyme is about 3 days (that is, each molecule of CYP1B1 is replaced by a new one roughly every three days).

Some substances inhibit the CYP1B1 enzyme. Once an inhibitory substance reacts with the enzyme it is prevented from metabolising and activating Salvestrols. If inhibitors are present in your body, they will compete with Salvestrols to react with the CYP1B1 enzyme. The competition will depend, in part, on the relative levels of both the inhibitors and the salvestrols and their affinity for CYP1B1. Thus, if an inhibitor cannot be avoided, its effect can be partially countered by increasing the dosage of Salvestrols.

The inhibition from some inhibitors will last the full life cycle of the enzyme. It is important to reduce or eliminate exposure to inhibitors to give Salvestrols their best chance of being activated. Strong inhibitors of CYP1B1 include carbon monoxide (e.g. in tobacco smoke), vitamin B17 (also known as amygdalin or laetrile), resveratrol in supplement strength (a few glasses of wine is okay), possibly pterostilbene, and naringinen (from grapefruit). Weaker inhibitors include hesperetin, cannabis, gingko biloba, ginseng and St. John's wort. Artificial sweeteners, including Stevia, can interfere with the absorption of Salvestrols: Calcium D Glucarate and other compounds found in natural and artificial sweeteners (except for honey) will interfere with the absorption of Salvestrols and their entry into the cancer cells and should thus be avoided. Quercetin and other bioflavonoids are not an issue when taken through diet but some may be inhibitors if taken in supplement form. Metformin, commonly used in the treatment of Type 2 Diabetes, is a Salvestrol inhibitor.

Certain agrochemical fungicides can also be a problem and these are doubly problematic. When used on crops they impair the plant's production of salvestrols. The plants will only produce the salvestrols in abundance when under attack from pathogens. But, in addition, inside the body these same fungicides can inhibit the metabolic activity of the CYP1B1 enzyme in the same way as does Vitamin B17, i.e., binding with the enzyme in a benign manner and thus blocking the metabolism of Salvestrols.

As a further complication, agrochemical fungicides are used in agriculture but are also found elsewhere which makes their avoidance difficult. Fungicides can be used on golf courses, public park areas, in new carpeting, dandruff shampoos, house paints and can be added to the cleaning agents used when heating ductwork is cleaned.

What should I avoid: The special case of cannabis.

As noted above cannabis is a weak inhibitor. There is some confusion on the Internet about this fact but it is true. There are three cannabinoids that inhibit CYP1B1: delta(9)-tetrahydrocannabinol (THC), cannabidiol, and cannabinol. It would be difficult to find a cannabis product that does not contain at least one of these cannabinoids. Unfortunately, once inhibited, the CYP1B1 enzyme cannot metabolise Salvestrols.

When an enzyme substrate (such as Salvestrol) is consumed with an enzyme inhibitor (such as cannabis) the one that will occupy the most binding sites on the enzyme depends on the relative blood concentrations of each and their relative affinity for the enzyme. If you must consume a cannabis product taking it and Salvestrols at different times is not a workable solution because the inhibitor will occupy the binding site for the life of the enzyme which is about 3 days. The only productive approach is to increase the amount of Salvestrols to partially counter the effect of the inhibitor.

Are Salvestrols antioxidants?

Some salvestrols are antioxidants and some are not. Antioxidants work by reducing cell DNA damage from free-radicals whereas salvestrols work through a specific mechanism that acts after cell damage has occurred, that is, they are effective beyond the point where normal antioxidants cease to be useful.

Are salvestrols suitable for children?

Yes, but children younger than twelve (12) years old should only take salvestrols under guidance from a physician.

Is resveratrol a salvestrol?

Yes, but it is not possible to dose it effectively. Although resveratrol is a good antioxidant, its effective dosage range as a salvestrol is very narrow. At higher concentrations, it is an inhibitor of CYP1B1. It is not possible to determine the dose at which the inhibition starts but we know that it is very low. Given this, it should be avoided while taking salvestrols.

Are salvestrols suitable for pets?

Salvestrols can be even more effective for dogs than humans and may work for other animals as well. Use one Salvestrol Platinum 2000 capsule with one meal per day for every 40 pounds that the dog weighs. For smaller dogs, empty the contents of the capsule proportionally by the pet's weight into each meal. If the dog does not respond after two weeks, gradually increase the dosage up to two Salvestrol Platinum 2,000 salvestrol point per meal.

Some people believe it is dangerous for dogs to consume grapes or products containing grape extracts. Despite information to contrary on the internet, Salvestrols in North America do not contain grape extracts nor are the compounds extracted from grape products. Furthermore, the Salvestrol Platinum 2000 blend is exacty the same as the discontinued product Salvestrol Platinum 1000 except there is twice the strength in the former (current) product.

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Statements on this site have not been evaluated by Health Canada. These products are not intended to diagnose, prevent, treat, or cure any disease. Please consult a qualified healthcare practitioner for medical advice.