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Questions and Answers

Please return to read this page frequently. The contents will change as new information is received from both research and feedback from people using salvestrols.

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Are salvestrols safe?

Even at well beyond the recommended number of Salvestrol Points per day there is no known toxicity, even for diabetics. However, Salvestrols should not be used by pregnant women and breast-feeding mothers.

What's in the capsules?

Salvestrol capsules consist of fruit and vegetable powder as follows: 300 mg of mixed citrus standardized to 25% citrus bioflavonoids expressed as polyphenols, 75mg of dried pumpkin (winter squash), and 75mg of grape seed extract (please note that this extract is not derived from grapefruit seed or grape skin). None of the contents have been genetically modified or treated with pesticides or anti-fungal agents. Salvestrols are encased in vegetable capsules containing a citrus background filler. The quantity of magnesium stearate used in the encapsulation process is very small and is vegetable quality specifically designed for use in the manufacture of food products.

What about grapefruit, grapes and their seed extracts?

As noted above, Salvestrol capsules are partially composed of an extract from the seeds of grapes. In the past people have asked us about Salvestrols in relation to grapefruit, grapes and their extracts. Grapefruit contains naringenin which is a CYP enzyme inhibitor and should be avoided if taking prescription medicines or Salvestrols. Salvestrols do not contain grapefruit or grapefruit extracts since this would inhibit the enzyme targeted by the product. Grapes (as opposed to grape seeds) are said to be harmful for dogs to consume. Many of our customers use Salvestrols for dogs which is safe to do because grape seeds and grape seed extracts are not harmful to dogs.

Are there any side effects?

There are no known issues with Salvestrol Platinum.

How many capsules should I do?

Until a blood test is available which can measure the presence of the CYP1B1 enzyme, its co-factors and inhibitors, accurate person-specific guidance for Salvestrol use cannot be provided. However, your healthcare professional can access the Practitioner's Area of our website on your behalf and advise you on the current guidelines for maximum effectiveness.

To confront a serious health challenge you should definitely consult a healthcare practitioner for advice. A healthcare professional can guide you on dosage and what to do and what to avoid to enhance the effective of Salvestrols. However, in general Salvestrol Platinum should be used as follows. People of normal weight (BMI 18 to 30) should use a total of six thousand (6,000) salvestrol points per day (4,000 at breakast and the rest at lunch); underweight people should take four thousand (4,000) salvestrol points per day; and heavier people should use eight thousand (8,000) salvestrol points per day. If there is no effect at the recommended starting dose, and you have eliminated factors that could interfere with the effectiveness of Salvestrols (see below), then you can gradually increase the daily intake by a capsule or two per week until the dosage is doubled. Salvestrol capsules should be taken with meals to facilitate digestive uptake. Please note that these guidelines do not apply to children.

For prevention or dealing with a previous health challenge first complete the following cleansing program: four thousand (4,000) salvestrol points per day for at least two months, followed by two thousand (2,000) salvestrol points a day for at least another two months. The cleansing program is required because disease can grow undetected for years so it is necessary to reduce the problem, if it exists, to a manageable level. After the cleansing program, adopt one of the following two regimens:

For a previous health challenge or people at higher risk, continue using at least two thousand (2,000) salvestrol points per day with a meal (either breakfast or dinner).

As a dietary supplement for prevention, take two thousand (2,000) salvestrol points per day.

How should I use LypoSalve Adaptive Skin Care?

LypoSalve Adaptive Skin Care (the new liposomal form of Salvestrol Cream) is designed for topical use in combination with at least one capsule of encapsulated salvestrol per day. LypoSalve Adaptive Skin Care does not work faster or better if more is applied; use only enough to lightly cover the affected area. LypoSalve Adaptive Skin Care can be applied several times daily, depending on the severity of the problem, over as large an area as necessary, but should not be applied directly to an open sore. There are no known allergic reactions to LypoSalve Adaptive Skin Care.

Will salvestrols interfere with drug therapies?

Salvestrols are a food supplement and should not interfere with drug therapies unless such therapies restrict intake of the fruit sources listed on the product label. Please note that salvestrol products do not contain naringenin, a compound commonly found in grapefruit which may interact with several CYP enzymes and could therefore interfere with some drug therapies.

If you or your physician are uncertain, stop using salvestrols several days prior to treatment and do not continue their use until several days after treatment has finished.

What can help salvestrols work better?

It is especially helpful to take a healthy dose (as much as one gram daily) of Vitamin C.

Taking multi-vitamin and multi-mineral supplements at the recommended daily allowance can increase the effectiveness of salvestrols. The specific enhancers are Biotin (Vitamin H, or Coenzyme R), Niacin (Vitamin B3), cobalamin (vitamin B12), magnesium, and selenium. Niacin, in a form that does not cause flushing or a skin rash (Nicotinimide), was previously included but is not present in the current formulation. These enhancers can be commonly found in daily vitamin and mineral supplements.

A Probiotic can improve the uptake of salvestrols; Probiotics are available at any health food store and many drug stores. Probiotic yogurts are available at most grocery stores and if you have problems swallowing capsules you can break them apart and mix them in the yogurt. It is important not to be anemic so a good source of iron is beneficial, as is vitamin C. Exercise is important to increase oxygen levels, especially about three hours after taking salvestrols. Finally, consider eating organic foods as much as possible.

The effectiveness of all the cytochrome P450 enzymes can be compromised when by anemia. It is best to consult a physician to check your iron levels and prescribe a course of action to remedy the situation if they are deficient before doing salvestrols.

What should I avoid while taking salvestrols?

Since many different substances can bind with the CYP1B1 enzyme the metabolism of Salvestrols can be inhibited. Given that the life cycle of the CYP1B1 enzyme is about 3 days (it is replaced by a new one roughly every three days) this can be problematic because certain substances will remain bound to the enzyme for the remainder of its life cycle. These substances are irreversible inhibitors that prevent the enzyme from metabolising Salvestrols. Agricultural and industrial anti-fungal chemicals are examples of irreversible inhibitors. Other substances are not true irreversible inhibitors but because they take a long time to clear from the body can act the same way. An example of such an inhibitor is St. John's Wort. These substances must also be avoided while taking Salvestrols. Other substances can partially inhibit the CYP1B1 enzyme but there are ways to counteract their effects. Finally, Calcium D Glucarate and compounds found in natural and artificial sweeteners can interfere with the absorption of Salvestrols and should be avoided but their effects can be similarly counteracted.

So what can be done to counter the effects of inhibitors? The best course of action would be to avoid inhibitors completely but sometimes this is not possible or even desirable. For example, your healthcare practitioner may have recommended an inhibitor to achieve other benefits (e.g., cannabis is often recommended to help with sleep, pain or appetite issues). If an inhibitor cannot be avoided its effect can be countered by increasing the dosage of Salvestrols. Which compound then binds with the most instances of the CYP1B1 enzyme largely comes down to which has the highest concentration in the blood. Thus, ingesting more Salvestrols will have the effect of increasing the likelihood of Salvestrol binding with CYP1B1 rather than the inhibitor. This situation will probably not reduce the effectiveness of the other compound because the desired mode of action of that substance is likely not through being metabolised by CYP1B1; it just happens to react with it. Given this, the effectiveness of the other compound may even increase.

Another way to counter the effect of an inhibitor, and one that can be coupled with an increased dose, would be to ingest Salvestrols in the morning (at or before breakfast and lunch) and postpone the use of an inhibitor (such as cannabinoids) until the mid-afternoon or evening. This would yield a high concentration of Salvestrols in the blood earlier in the day without competition, allowing maximum effectiveness, and offer the same situation to the inhibitor later on when the concentration of Salvestrols is waning. This solution allows both compounds to be effective, a win-win situation.

These solutions and the inhibitors they are designed to counteract are summarized in the table below:

Inhibitory Effect Substance Remedy
Complete St. John's Wort (hypericin)
Agricultural and industrial anti-fungal chemicals
Calcium D glucarate (see Note 1 below)
Carbon monoxide (see Note 2 below)
None
Partial Artificial sweeteners (stevia, xylitol, etc., see Note below)
Cannabis (medical: CBD, CBN and recreational: THC)
Gingko biloba
Gingseng
Grapefruit juice (naringenin)
Metformin
Resveratrol (in supplement strength)
Vitamin B17 (amygdalin, laetrile, apricot kernels)

1. Increase Salvestrol dosage and/or

2. Take Salvestrol earlier in the day and other substances in late afternoon or evening
    to minimize inhibition.

Notes:

  1. Calcium D glucarate inhibits beta-glucuronidase which aids transport within the body and should not be taken if using Salvestrols.
  2. A partial solution for habitual smokers is to take Salvestrols before going to sleep to allow sufficient time for them to work without
    interference from carbon monoxide (it isn't the nicotine that inhibits the enzyme).
  3. Honey should used in place of sugar or artificial sweeteners. Small amounts embedded in a supplement are fine.

Are Salvestrols antioxidants?

Some salvestrols are antioxidants and some are not. Antioxidants work by reducing cell DNA damage from free-radicals whereas salvestrols work through a specific mechanism that acts after cell damage has occurred, that is, they are effective beyond the point where normal antioxidants cease to be useful.

Are salvestrols suitable for children?

Yes, but children younger than twelve (12) years old should only take salvestrols under guidance from a physician.

Is resveratrol a salvestrol?

Yes, but it is not possible to dose it effectively. Although resveratrol is a good antioxidant, its effective dosage range as a salvestrol is very narrow. At higher concentrations, it is an inhibitor of CYP1B1. It is not possible to determine the dose at which the inhibition starts but we know that it is very low. Given this, it should not be taken at supplement strength while taking salvestrols.

Are salvestrols suitable for pets?

Salvestrols can be even more effective for dogs than humans and may work for other animals as well. Use one Salvestrol Platinum 2000 capsule with one meal per day for every 40 pounds that the dog weighs. For smaller dogs, empty the contents of the capsule proportionally by the pet's weight into each meal. If the dog does not respond after two weeks, gradually increase the dosage up to two Salvestrol Platinum 2,000 salvestrol points per meal.


Salvestrols
Victoria: 250-483-3640
M-F 9:00a to 4:30p PT
Toll-free: 1-866-837-1523
Email: sales@salvestrol.ca

Statements on this site have not been evaluated by Health Canada. These products are not intended to diagnose, prevent, treat, or cure any disease. Please consult a qualified healthcare practitioner for medical advice.