Even at well beyond the recommended number of Salvestrol Points per day there is no known toxicity, even for diabetics. However, Salvestrols should not be used by pregnant women and breast-feeding mothers.

Salvestrols are made from organically grown fruit. The content of each capsule is listed on the product labels (scroll down to view the appropriate product). In general, salvestrols are extracted in high concentrations from tangerine or orange peel and blueberries and mixed with concentrated blackberry and strawberry powder.

Although rare, some people may experience a mild stomach discomfort or a mild laxative effect from high doses of Salvestrol Professional. If this manifests as diarrhoea then Salvestrol Professional should be stopped for three days, or until the diarrhoea has cleared up, and then started again. This is not an issue with other salvestrol products.

In August, 2010 Salvestrol Professional and Salvestrol Gold will be retired as separate products, leaving only Salvestrol Platinum. Salvestrol Platinum is a blend of a four Salvestrols including the compounds in Salvestrol Professional and Salvestrol Gold and two new, more highly selective Salvestrols. Each Salvestrol Platinum 1000 capsule is three times the strengh of the former Salvestrol Professional or Salvestrol Gold capsules. Salvestrol Cream is designed for topical application.

Until a blood test is available which can measure the presence of the CYP1B1 enzyme, its co-factors and inhibitors, accurate person-specific guidance for Salvestrol use cannot be provided. Your healthcare professional can access the Practitioner's Area of our website to view current guidelines for maximum effectiveness. Because of the associated digestive processes, Salvestrols should be taken with a meal.

To confront a serious health challenge, use Salvestrol Platinum 1000. Normal to slightly overweight people (BMI 18 to 30) should use a total of five capsules (two at breakfast and dinner and one at lunch, or three at breakfast and two at dinner); underweight people should use four capsules (two at breakfast and dinner); and overweight people should use six capsules (two at breakfast, lunch and dinner). These guidelines do not apply to children.

For prevention or dealing with a previous health challenge first complete the following cleansing program: take four capsules of Salvestrol Platinum 1000 (two at breakfast and two at dinner) for at least two months, followed by two capsules of Salvestrol Platinum 1000 (two at breakfast or dinner) for at least another two months. The cleansing program is required because disease can grow undetected for years so it is necessary to reduce the problem, if it exists, to a manageable level. After the cleansing program, adopt one of the following two regimens:

For a previous health challenge or people at higher risk, use Salvestrol Platinum 1000, two capsules per day (together at either breakfast or dinner).

As a dietary supplement for prevention, take one capsule per day of Salvestrol Platinum 1000.

Salvestrol Cream is designed for topical use in combination with at least one capsule of encapsulated salvestrol per day. Salvestrol Cream does not work faster or better if more is applied; use only enough to lightly cover the affected area. Salvestrol Cream can be applied several times daily, depending on the severity of the problem, over as large an area as necessary, but should not be applied directly to an open sore. There are no known allergic reactions to Salvestrol Cream.

Salvestrols are a food supplement and should not interfere with drug therapies unless such therapies restrict intake of the fruit sources listed on the product label. Please note that salvestrol products do not contain naringenin, a compound commonly found in grapefruit which may interact with several CYP enzymes and could therefore interfere with some drug therapies.

If you are uncertain, stop using salvestrols several days prior to treatment and do not continue their use until several days after treatment has finished.

Taking multi-vitamin and multi-mineral supplements at the recommended daily allowance can increase the effectiveness of salvestrols. The specific enhancers are Biotin (Vitamin H), Niacin (Vitamin B3), magnesium, and selenium. Niacin, in a form that does not cause flushing or a skin rash (Nicotinimide), was previously included but is not present in the current formulation. These enhancers can be commonly found in daily vitamin and mineral supplements. It is also helpful to use a Probiotic since this can improve the uptake of salvestrols; Probiotics are available at any health food store and many drug stores. Finally, you should also exercise (to increase oxygen levels) and consider switching to organic foods.

The CYP1B1 enzyme can react with many different substances aside from Salvestrols. The life cycle of the enzyme is about 3 days (that is, each molecule of CYP1B1 is replaced by a new one roughly every three days).

Some substances inhibit the CYP1B1 enzyme. Once an inhibitory substance reacts with the enzyme it is prevented from metabolising and activating Salvestrols. If inhibitors are present in your body, they will compete with salvestrols to react with the CYP1B1 enzyme. The competition will depend, in part, on the relative levels of both the inhibitors and the salvestrols and their affinity for CYP1B1.

The inhibition from some inhibitors will last the full life cycle of the enzyme. It is important to reduce or eliminate exposure to inhibitors to give Salvestrols their best chance of being activated. Strong inhibitors of CYP1B1 include carbon monoxide (e.g. in tobacco smoke), vitamin B17 (also known as amygdalin or laetrile), resveratrol, and certain agrochemical fungicides.

Agrochemical fungicides are doubly problematic. When used on crops they impair the plant's production of salvestrols. The plants will only produce the salvestrols in abundance when under attack from pathogens. But, in addition, inside the body these same fungicides can inhibit the metabolic activity of the CYP1B1 enzyme in the same way as does Vitamin B17, i.e., binding with the enzyme in a benign manner and thus reducing or eliminating the metabolism of salvestrols.

As a further complication, agrochemical fungicides are used in agriculture but are also found elsewhere which makes their avoidance difficult. Fungicides can be used on golf courses, public park areas, in new carpeting, dandruff shampoos, house paints and can be added to the cleaning agents used when heating ductwork is cleaned.

Some salvestrols are antioxidants and some are not. Antioxidants work by reducing cell DNA damage from free-radicals whereas salvestrols work through a specific mechanism that acts after cell damage has occurred, that is, they are effective beyond the point where normal antioxidants cease to be useful.

Yes, but children younger than twelve (12) years old should only take salvestrols under guidance from a physician.

Yes, but it is not possible to dose it effectively. Although resveratrol is a good antioxidant, its effective dosage range as a salvestrol is very narrow. At higher concentrations, it is an inhibitor of CYP1B1. It is not possible to determine the dose at which the inhibition starts but we know that it is very low. Given this, it should be avoided while taking salvestrols.

Salvestrols may be less effective for cats because they do not produce the CYP1B1 enzyme in the same way as humans but the results for dogs may actually be superior. Empty the contents of one Professional or Gold capsule for every 15 pounds, or one Platinum 1000 capsule per 43 pounds, in the pet's meal per day. For larger pets, split the capsules between meals if they eat twice a day.